STOP360
Computer screen showing a patient being randomly assigned a treatment option.
Computer screen showing a patient being randomly assigned a treatment option.

Study treatment

If you join the study, you will get one or two IV (intravenous) antibiotics to treat your exacerbation.

A computer will randomly assign half of the people in the study to get 2 antibiotics and half of the people to get 1 antibiotic.

You will have a 50/50 chance of getting either:

2 Antibiotics

Beta-lactam + Aminoglycoside

example: ceftazidime + tobramycin

or

1 Antibiotic

Beta-lactam

example: ceftazidime

Both treatments will be done the same way:

  • You will get the antibiotics for about 14 days.
  • Your IV treatment can be done in the hospital or at home. You and your care team will know which treatment you are getting.
  • You will be asked not to take oral or inhaled antibiotics that work against Pseudomonas from your first visit until your second visit in about four weeks. This includes ciprofloxacin and tobramycin, such as TOBI.

If you do not join the study:

  • Your care team will work with you to decide which antibiotics to use.
  • Doctors usually treat pulmonary exacerbations with a beta-lactam and an aminoglycoside together for about 14 days.
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